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KMID : 0381019860190050296
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Korean Journal of Nutrition
1986 Volume.19 No. 5 p.296 ~ p.303
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Effect of Human Plasma Lipid Transfer Protein on the Distribution of Lipids Between Lipoprotein Fractions of Rat Plasma
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Choi Young-Sun
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Abstract
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Rat lipoproteindeficient plasma possessed a lip-
id transfer inhibitory activity when it was added to purified human plasma lipid transfer protein, while it lacked a lipid transfer activity. Incubation of whole rat plasma with partially purified human lipid transfer protein resulted in big changes in lipid distribution of rat plasma lipoproteins. There was a 4-fold increase in cholesteryl ester(CE) and 47% reduction in triglyceride(TG) in very low density lipoproteins after 24hour incubation. In high density lipoprotein 2(HDL2) there was a 9-fold increase in TG and 33 % reduction in CE. HDL3 had 82% reduction in CE. The result indicates that the absence of the lipid transfer activity in rat plasma can be ascribed not to the inability of rat lipoproteins to serve as substrates but to the lack of the lipid transfer protein in rat plasma. Therefore, species differences in lipid transfer between lipoproteins should be taken into consideration to interpret results of studies on lipoprotein metabolism using rats.
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KEYWORD
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